Three new vaccines are being developed to tackle the rare species of Ebola that has already killed nearly 250 people.<\/p>\n
The International Aids Vaccine Initiative (IAVI), which is working on one vaccine, said the outbreak was threatening to be the worst ever.<\/p>\n
The University of Oxford and the pharma company Moderna are also researching vaccines against the Bundibugyo species.<\/p>\n
The Coalition for Epidemic Preparedness Innovations, which is providing funding to each group, said \u00ab\u00a0every day counts\u00a0\u00bb.<\/p>\n
There are now more than 1,000 suspected cases in the DR Congo with nine confirmed cases in neighbouring Uganda.<\/p>\n
There is growing concern this outbreak \u2013 which was detected only after it had spread in a conflict zone with limited healthcare resources \u2013 could reach the size of the largest ever Ebola outbreak in West Africa in 2014-16. Then, nearly 29,000 people were infected and more than 11,000 died.<\/p>\n
Dr Mark Feinberg, head of IAVI, said: \u00ab\u00a0I think this is clearly threatening to be as severe an outbreak as that, if not even worse, and development of a vaccine, and other countermeasures, is clearly a priority.\u00a0\u00bb<\/p>\n
It echoes concerns from the medical charity M\u00e9decins Sans Fronti\u00e8res (MSF) which said the situation was \u00ab\u00a0deeply alarming\u00a0\u00bb and never before had \u00ab\u00a0so many cases\u00a0\u00bb been recorded so soon.<\/p>\n
Vaccines must be developed for each individual species of Ebola \u2013 there are six, but only three are known to cause outbreaks.<\/p>\n
There is a vaccine for the most common Zaire species, but this outbreak is being caused by another species, called Bundibugyo. It has only been seen twice before and there is no approved vaccine.<\/p>\n
IAVI is working on a modified version of the Zaire Ebola vaccine to fight Bundibugyo. The experimental jab has been tested in monkeys where it rapidly trained the immune system and gave close to 100% protection.<\/p>\n
Feinberg said their evidence so far meant he was \u00ab\u00a0optimistic about the potential\u00a0\u00bb, but currently it would take seven to nine months to get the vaccine ready for clinical trials – although they are trying to \u00ab\u00a0accelerate those timelines\u00a0\u00bb.<\/p>\n
Meanwhile, the pharmaceutical company Moderna has announced it is using its mRNA technology \u2013 which was deployed to rapidly develop vaccines in the Covid pandemic \u2013 to work on Bundibugyo.<\/p>\n
\u00ab\u00a0We will move with urgency and scientific rigor to support the response and help bring a potential vaccine closer to the communities that need it most,\u00a0\u00bb said St\u00e9phane Bancel, chief executive officer of Moderna.<\/p>\n
And the University of Oxford has already said it is working on its own vaccine technology, which also saved lives in Covid, to develop a fresh Ebola vaccine.<\/p>\n
This should be ready for clinical trials in two to three months.<\/p>\n
Each vaccine aims to train the body to spot the same structure on the surface of the virus \u2013 known as the Bundibugyo glycoprotein. However, each uses a different technology to get there.<\/p>\n
IAVI uses a live, but harmless virus that has been engineered so it also has the Ebola glycoprotein. The immune system fights off the harmless virus and learns to fight Ebola in the process.<\/p>\n
The mRNA vaccine and the Oxford vaccine both deliver a snippet of genetic code into the body. Once inside it orders the construction of the Bundibugyo glycoprotein, which the body recognises as foreign and starts to attack.<\/p>\n
All would mean that the immune system has a head start when it comes to fighting a real Ebola infection.<\/p>\n
However, differences in the technologies and the way they train the immune system could affect levels of protection or the number of doses needed. All this needs to be tested in clinical trials.<\/p>\n
The Coalition for Epidemic Preparedness Innovations (Cepi) is funding the early stages of research.<\/p>\n
\u00ab\u00a0With Bundibugyo virus spreading rapidly and no licensed vaccines, every day counts in the race against this deadly disease,\u00a0\u00bb said Dr Richard Hatchett, CEO of CEPI.<\/p>\n
Dr Tedros Adhanom Ghebreyesus, the director general of the World Health Organization, said: \u00ab\u00a0A Bundibugyo vaccine could help to control this epidemic and strengthen preparedness for future outbreaks.\u00a0\u00bb<\/p>\n","protected":false},"excerpt":{"rendered":"
Three new vaccines are being developed to tackle the rare species of Ebola that has already killed nearly 250 people. The International Aids Vaccine Initiative (IAVI), which is working on one vaccine, said the outbreak was threatening to be the worst ever. The University of Oxford and the pharma company Moderna are also researching vaccines […]<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":{"0":"post-10186","1":"post","2":"type-post","3":"status-publish","4":"format-standard","6":"category-uncategorized"},"_links":{"self":[{"href":"https:\/\/placedesnations.org\/index.php\/wp-json\/wp\/v2\/posts\/10186","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/placedesnations.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/placedesnations.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/placedesnations.org\/index.php\/wp-json\/wp\/v2\/comments?post=10186"}],"version-history":[{"count":0,"href":"https:\/\/placedesnations.org\/index.php\/wp-json\/wp\/v2\/posts\/10186\/revisions"}],"wp:attachment":[{"href":"https:\/\/placedesnations.org\/index.php\/wp-json\/wp\/v2\/media?parent=10186"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/placedesnations.org\/index.php\/wp-json\/wp\/v2\/categories?post=10186"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/placedesnations.org\/index.php\/wp-json\/wp\/v2\/tags?post=10186"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}